Scooby-Doo! Mystery Mayhem is a third-person action-adventure video game based on the Scooby-Doo franchise. The game was developed by Artificial Mind and Movement and published by THQ in 2003 for the Game Boy Advance. It was later released for the PlayStation 2, GameCube, and Xbox in 2004.

When Scooby and the gang discover that someone has released thousands of real ghosts and monsters from a magic book called The Tome of Doom, they race to solve mysteries and put the monsters back into it. The gang explore five locations, including: Hambridge Library, the Milton Brothers Movie Studio, the Gold Mountain western theme park, a bayou, and Sherman-Tech Headquarters in Colorado.